Therefore, specialized mi software may be useful for people who expect to conduct mi regularly. Multiple imputation relies on regression models to predict the missingness and missing values, and incorporates uncertainty through an iterative approach. I examine two approaches to multiple imputation that have been incorporated into widely available software. Reporting the results although the use of multiple imputation and other missing data procedures is increasing, however many modern missing data procedures are still largely misunderstood. See also joseph schafer s multiple imputation faq page for introductory explanations and further references. Many research studies have used multiple imputation e. Ml and mi are now becoming standard because of implementations in free and commercial software. In the missing data literature, pan has been recommended for mi of multilevel data. Graham pennsylvania state university statistical procedures for missing data have vastly improved, yet miscon ception and unsound practice still abound. Multiple imputation inference involves three distinct phases. Both articles discuss various available software for multiple imputation and their utility for sem. The following is the procedure for conducting the multiple imputation for missing data that was created by. Accounting for missing data in statistical analyses. Jun 29, 2009 multiple imputation has potential to improve the validity of medical research.
Statas new mi command provides a full suite of multipleimputation methods for the analysis of incomplete data, data for which some values are missing. The m complete data sets are analyzed by using standard procedures. Flexible, free software for multilevel multiple imputation. Four studies investigated specialized situations for multiple imputation, such as smallsample degrees of freedom in da barnard and rubin 1999, likertscale data in da leite and beretvas 2010, nonparametric multiple imputation cranmer and gill 20, and variance estimators hughes, sterne, and tilling 2016. Schafer, j l and olsen, m k 1 998 multiple imputation for multivariate missingdata problems. See enders 2010 for a discussion of other statistical software packages that can perform multiple imputation and other modern missing data procedures. New computational algorithms and software described in a recent book schafer, 1997a allow us to create proper multiple imputations in.
Computational routines used in norm are described by schafer, j. A comparison of multiple imputation methods for missing data. In recent years, multiple imputation has emerged as a convenient and flexible. Feb 24, 2011 multiple imputation involves filling in the missing values multiple times, creating multiple complete datasets. Abstract multiple imputation provides a useful strategy for dealing with data sets that have missing values. Columnwise speci cation of the imputation model section3. What is the best statistical software to handling missing data. The performance of multiple imputation for likerttype items. Individual researchers now routinely use multiple imputation for missing data in small samples, as evidenced by the development of multiple imputation procedures for mainstream software like sas, stata, and splus. Multiple imputation of incomplete multivariate data under a normal model. Nov 07, 2001 comparison of proc impute and schafer s multiple imputation software. In the last two decades, multiple imputation has evolved beyond the context of large sample survey nonresponse. Multiple imputation in a largescale complex survey.
Compares solas, sas, mice, splus implementations of imputation. Multiple imputation involves filling in the missing values multiple times, creating multiple complete datasets. It also includes appendices showing splus functions for continuous variables, categorical variables, and mixed variables in schafers multiple imputation software. Key advantages over a complete case analysis are that it preserves n without introducing bias if data are mar, and provides corrects ses for uncertainty due to missing values.
Why you probably need more imputations than you think. Rubin 1987 book on multiple imputation schafer 1997 book on mcmc and multiple imputation for missingdata problems more subjectoriented carpenter, j. However, the multiple imputation procedure requires the user to model the distribution of each variable with missing values, in terms of the observed data. Norm users guide the methodology center penn state. The results from the m complete data sets are combined for the inference.
However, programming ones own multiple imputation algorithm is considerably more challenging than the programming required to specify analysis models in most evaluations. The report ends with a summary of other software available for missing data and a list of the useful references that guided this report. Multiple imputation mi is often presented as an improvement over listwise deletion lwd for regression estimation in the presence of missing data. New computational algorithms and software described in a recent book schafer, 1997a allow us to create proper multiple imputations in complex multivariate settings. Multiple imputation in multivariate problems when the imputation and analysis models differ joseph l. Multiple imputation for missing data in epidemiological and. Multiple imputation mi is now widely used to handle missing data in longitudinal studies. They summarize the evidence against older procedures and, with few exceptions. Multiple imputation mi is a way to deal with nonresponse bias missing research data that.
Development of this software has been supported by grant 2r44ca6514702 from. The treatment of missing data can be difficult in multilevel research because stateoftheart procedures such as multiple imputation mi may require advanced statistical knowledge or a high degree of familiarity with certain statistical software. Schafer 1997, van buuren and oudshoom 2000 and raghunathan et al. Mathematical, physical and engineering sciences, 10.
Multiple imputation for missing data is an attractive method for handling missing data in multivariate analysis. Jun 10, 2010 new computational algorithms and software described in a recent book schafer, 1997a allow us to create proper multiple imputations in complex multivariate settings. Reweighting, long used by survey methodologists, has been proposed for handling missing values in regression models with missing covariates ibrahim, 1990. Multiple imputation for continuous and categorical data. Following the seminal books by rubin 1987 and schafer 1997, mi has. National center for education statistics working paper series comparison of proc impute and schafers multiple imputation software working paper no. In this paper, we document a study that involved applying a multiple imputation technique with chained equations to data drawn from the 2007 iteration of the timss database. Most popular statistical software packages have options for multiple imputation, which require little. When can multiple imputation improve regression estimates. Clearly the method of imputation plays a key role in success of the multiple imputation methods. To learn more about multiple imputation see rubin, 1987, 1996.
Comparison of proc impute and schafers multiple imputation. The idea of multiple imputation for missing data was first proposed by rubin 1977. Multiple imputationnuts and bolts mi can import already imputed data from nhanes or ice, or you can start with original data and form imputations yourself. Multiple imputation an overview sciencedirect topics. This report provides detailed evaluations of both software packages as well as comparing the packages. Comparison of proc impute and schafers multiple imputation software. Multiple imputation using chained equations for missing. New computational algorithms and software described in a recent book schafer, 1997 allow us to create proper multiple imputations in complex multivariate settings. Multiple imputation can be used by researchers on many analytic levels.
Described in detail by schafer and graham 2002, the missing values are imputed based on the observed values for a given individual and the relations observed in the data for other participants, assuming the observed. Multiple imputation using sas software yang yuan sas institute inc. Schafer department of statistics and the methodology center, the pennsylvania state university, 326 thomas building, university park, pa 16802, usa. The validity of results from multiple imputation depends on such modelling being done carefully and appropriately. Multiple imputation is an attractive choice as a solution to missing data problems because it represents a good balance between quality of results and ease of use. An imputation represents one set of plausible values for missing data, and so multiple imputations represent multiple sets of plausible values. It also includes appendices showing splus functions for continuous variables, categorical variables, and mixed variables in schafer s multiple imputation software. The twolevel imputation algorithm is a combination of three existing multiple imputation algorithms. However, one of the big uncertainties about the practice of multiple imputation is how many imputed data sets are needed to get good results.
Multiple imputation for missing data statistics solutions. There is currently only a limited amount of software for generating multiple imputations under multivariate completedata models and for analyzing multiplyimputed data sets i. Missing data analysis using multiple imputation circulation. Either way, dealing with the multiple copies of the data is the bane of mi analysis. See also joseph schafers multiple imputation faq page for introductory explanations and further references. Stata only the most recent version 12 has a builtin comprehensive and easy to use module for multiple imputation, including multivariate imputation using chained equations. Conceived by rubin and described further by little and rubin and schafer, multiple imputation imputes each missing value multiple times.
Joseph l schafer department of statistics, the pennsylvania state university. Instead of lling in a single value for each missing value, a multiple imputation procedure replaces each missing value with a set of plausible values that represent the. Multiple imputation has potential to improve the validity of medical research. Against a common view, we demonstrate anew that the complete case estimator can be unbiased, even if data are not missing completely at random. Features this paper describes the r package mice 2.
Some of the most commonlyused software include r packages hmsic harrell 2011, function aregimpute, norm novo and schafer 2010, cat harding, tusell, and schafer 2011, mix schafer 2010 for a variety of techniques to create multiple imputations in continuous, categorical or mixture of continuous and categorical datasets. Missing data, multiple imputation and associated software. Comparison of proc impute and schafer s multiple imputation software. Several mi techniques have been proposed to impute incomplete longitudinal covariates, including standard fully conditional specification fcsstandard and joint multivariate normal imputation jmmvn, which treat repeated measurements as distinct variables, and various extensions based on. Department of education office of educational research and improvement. Using multiple imputation to address missing values of. Multiple imputation for missing data in epidemiological.
Missing data takes many forms and can be attributed to many causes. The development of diagnostic techniques for multiple imputation, though, has been retarded by the belief that the assumptions of the procedure are untestable from observed data. The top level of the data level 2 is imputed using an adaptation of the multiple imputation algorithm developed by tanner and wong 1987 and popularized by schafer 1997. Several mi techniques have been proposed to impute incomplete longitudinal covariates, including standard fully conditional specification fcsstandard and joint multivariate normal imputation jmmvn, which treat repeated measurements as distinct variables, and various extensions based on generalized. Joseph schafers list of multiple imputation software routines. Multiple imputation provides a useful strategy for dealing with data sets with missing values. Multiple imputation is a popular method for addressing data that are presumed to be missing at random. Smallsample degrees of freedom for multicomponent signi. A comparison of multiple imputation methods for missing. The performance of multiple imputation for likerttype. To obtain accurate results, ones imputation model must be congenial to appropriate for ones intended analysis model. The performance of multiple imputation in a variety of missing data situations has been. Schafer and graham 2002 and allison 2003 seem to be the two major articles that discuss employment of multiple imputation in sem.
Among these procedures, multiple imputation mi, together with maximum likelihood estimation, is becoming one of the preferred techniques for dealing with. The traditional multiple imputation method used by most commercial statistical software packages such as sas, iveware, etc. Some practical clarifications of multiple imputation theory. Mi has been adapted to a variety of different types of data for example, survival data. Jan 01, 2010 multiple imputation for missing income data in the national health interview survey. The mi procedure in the sasstat software is a multi. Nov 09, 2012 over the last decade, multiple imputation has rapidly become one of the most widelyused methods for handling missing data. Recai m yucel, multiple imputation inference for multivariate multilevel continuous data with ignorable nonresponse, philosophical transactions of the royal society a. Multiple imputation in multivariate problems when the. Schafer and olsen 1989 suggest that a good starting point is a number. Pdf statistical inference in missing data by mcmc and.
Finally, section 5 explains how to carry out multiple imputation and maximum likelihood using sas and stata. Multiple imputation for multivariate missingdata problems. With a slight abuse of the terminology, we will use the term imputation to mean the data where missing values are replaced with one set of plausible values. Multiple imputation mi is an approach for handling missing values in a dataset that allows researchers to use. An overview of the state of the art center for statistical research and methodology cs rm united states census bureau may16, 2015 views expressed are those of the author and not necessarily those of the u. Missing data and multiple imputation columbia university. Adapted from schafer, jl 1997b, introduction to multiple imputations for missing data problems, viewed 6 may 2002. The multiple imputation process using sas software imputation mechanisms the sas multiple imputation procedures assume that the missing data are missing at random mar, that is, the probability that an observation is missing may depend on the observed values but not the missing values. More precisely, we imputed missing variables contained in the student background datafile for tunisia one of the timss 2007 participating countries, by using van buuren, boshuizen, and knooks sm 18.